John C Chatham Selected Research

Acetylglucosamine

1/2022	Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart.
1/2021	Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases.
1/2019	O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activity.
3/2014	Activation of AKT by O-linked N-acetylglucosamine induces vascular calcification in diabetes mellitus.
3/2013	Cardiac O-GlcNAcylation blunts autophagic signaling in the diabetic heart.
1/2011	O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells.
11/2010	Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner.
2/2010	Increased O-linked beta-N-acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats.
3/2009	Evidence of O-linked N-acetylglucosamine in diabetic nephropathy.
2/2009	Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-{kappa}B signaling.

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John C Chatham Research Topics

Disease

15	Ischemia 01/2021 - 04/2002
8	Hyperglycemia 03/2014 - 04/2004
8	Hemorrhage 05/2011 - 06/2006
8	Wounds and Injuries (Trauma) 05/2011 - 06/2006
6	Insulin Resistance 01/2019 - 09/2006
4	Diabetes Mellitus 01/2021 - 01/2009
4	Diabetes Complications 01/2021 - 12/2014
4	Shock 12/2019 - 06/2006
4	Reperfusion Injury 01/2017 - 01/2007
4	Type 2 Diabetes Mellitus (MODY) 03/2011 - 09/2006
3	Heart Failure 01/2022 - 04/2002
3	Diabetic Cardiomyopathies 01/2022 - 04/2007
3	Hypertrophy 01/2020 - 03/2008
3	Neointima 01/2011 - 09/2002
2	Left Ventricular Dysfunction 01/2022 - 02/2009
2	Fibrosis (Cirrhosis) 01/2022 - 01/2020
2	Heart Diseases (Heart Disease) 01/2022 - 01/2017
2	Parkinson Disease (Parkinson's Disease) 01/2021 - 01/2017
2	Obesity 01/2021 - 10/2016
2	Chronic Disease (Chronic Diseases) 01/2021 - 10/2020
2	Inflammation (Inflammations) 01/2011 - 02/2010
2	Myocardial Ischemia (Ischemic Heart Diseases) 02/2010 - 07/2004
2	Hemorrhagic Shock 02/2009 - 09/2007
2	Necrosis 03/2008 - 01/2007
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2020
1	Glucose Intolerance 01/2020
1	Septic Shock (Toxic Shock Syndrome) 12/2019
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Breast Neoplasms (Breast Cancer) 01/2019
1	Neoplasms (Cancer) 01/2019
1	Epilepsy (Aura) 01/2017
1	Cardiomyopathies (Cardiomyopathy) 10/2016
1	Vascular Calcification 03/2014
1	Death (Near-Death Experience) 05/2011
1	Diabetic Nephropathies (Diabetic Nephropathy) 03/2009
1	Hydronephrosis 07/2007
1	Ischemic Contracture 05/2007

Drug/Important Bio-Agent (IBA)

30	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2006
17	AcetylglucosamineIBA 01/2022 - 06/2006
14	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 07/2004
13	Glucosamine (Dona)IBA 01/2011 - 04/2004
12	HexosaminesIBA 01/2020 - 04/2004
6	Fatty Acids (Saturated Fatty Acids)IBA 01/2017 - 04/2005
4	Insulin (Novolin)FDA Link 01/2019 - 07/2004
4	N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime (PUGNAC)IBA 01/2011 - 04/2007
4	CarbohydratesIBA 04/2007 - 07/2004
3	hexosaminidase CIBA 01/2020 - 01/2007
3	Lactic Acid (Lactate)FDA LinkGeneric 05/2005 - 07/2004
3	Pyruvic Acid (Pyruvate)IBA 05/2005 - 07/2004
2	thiamet GIBA 01/2021 - 03/2014
2	Streptozocin (Streptozotocin)FDA Link 01/2020 - 03/2014
2	salicylhydroxamic acid (SHAM)IBA 05/2011 - 02/2010
2	Glutamine (L-Glutamine)FDA Link 02/2010 - 01/2007
2	Mannitol (Osmitrol)FDA LinkGeneric 02/2010 - 09/2007
2	CalciumIBA 03/2008 - 02/2006
2	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/2007 - 04/2004
2	AzaserineIBA 01/2007 - 04/2004
2	Inositol (Myoinositol)IBA 01/2006 - 04/2004
2	PalmitatesIBA 05/2005 - 07/2004
2	Adenosine Triphosphate (ATP)IBA 07/2004 - 04/2002
1	SugarsIBA 01/2022
1	N-propionylprocainamideIBA 01/2022
1	ProteomeIBA 01/2021
1	Threonine (L-Threonine)FDA Link 01/2021
1	ChromatinIBA 01/2021
1	Branched-Chain Amino AcidsIBA 01/2021
1	Serine (L-Serine)FDA Link 01/2021
1	succinyl-coenzyme A (succinyl-CoA)IBA 01/2020
1	KetonesIBA 01/2020
1	C.I. direct red 80IBA 01/2020
1	Blood Glucose (Blood Sugar)IBA 01/2020
1	TransferasesIBA 01/2020
1	Hydroxybutyrate Dehydrogenase (3 Hydroxybutyrate Dehydrogenase)IBA 01/2020
1	CollagenIBA 01/2020
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2020
1	Coenzyme A (CoA)IBA 01/2020
1	LipopolysaccharidesIBA 12/2019
1	1,2- dideoxy- 2'- propylglucopyranoso(2,1- d)- delta 2'-thiazolineIBA 12/2019
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	SynucleinsIBA 01/2017
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 05/2011
1	N-acetylglucosamine thiazolineIBA 11/2010
1	Monoclonal AntibodiesIBA 05/2010
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 02/2010
1	CarbamatesIBA 02/2010
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 02/2010
1	PotassiumIBA 02/2010
1	Alanine Transaminase (SGPT)IBA 02/2010
1	Interleukin-6 (Interleukin 6)IBA 02/2010
1	4- (4- dihexadecylaminostyryl)- N- methylpyridium (DiA)IBA 02/2009
1	NF-kappa B (NF-kB)IBA 02/2009
1	CytokinesIBA 02/2009
1	Annexin A5IBA 03/2008
1	SolutionsIBA 09/2007
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 07/2007

Therapy/Procedure

9	Resuscitation 12/2019 - 06/2006
3	Therapeutics 01/2021 - 01/2017